HLA-A*33:01 as Protective Allele for Severe Dengue in a Population of Filipino Children

  title={HLA-A*33:01 as Protective Allele for Severe Dengue in a Population of Filipino Children},
  author={Edelwisa Segubre Mercado and Fe Esperanza Espino and Ma. Lucila M. Perez and Josie M. Bilar and Jemimah Dawn P. Bajaro and Nguyen Tien Huy and Benilda Q Baello and Mihoko Kikuchi and Kenji Hirayama},
  booktitle={PloS one},
Dengue virus infection is a leading cause of morbidity among children in the Philippines in recent years. In order to investigate the association of HLA Class I and II alleles and dengue disease severity in a cohort of Filipino children, we performed a case control study in 2 hospitals in Metro Manila from June 2008 to December 2009. A total of 250 laboratory confirmed dengue patients and 300 healthy individuals aged 5 to 15 years old were typed for HLA-A, B and DRB1 alleles. The frequency of… CONTINUE READING


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