HLA-A*2402-restricted HIV-1-specific cytotoxic T lymphocytes and escape mutation after ART with structured treatment interruptions.

@article{Tanuma2008HLAA2402restrictedHC,
  title={HLA-A*2402-restricted HIV-1-specific cytotoxic T lymphocytes and escape mutation after ART with structured treatment interruptions.},
  author={Junko Tanuma and Mamoru Fujiwara and Katsuji Teruya and Saori Matsuoka and Hikaru Yamanaka and Hiroyuki Gatanaga and Natsuo Tachikawa and Yoshimi Kikuchi and Masafumi Takiguchi and Shinichi Oka},
  journal={Microbes and infection},
  year={2008},
  volume={10 6},
  pages={689-98}
}
Although a limited duration of immune activation of structured treatment interruptions (STIs) has been reported, the immune escape mechanism during STIs remains obscure. We therefore investigated the role of three immunodominant cytotoxic T lymphocyte (epitopes) in 12 HLA-A*2402-positive patients participating longitudinally during the clinical study of early antiretroviral treatment (ART) with five series of structured treatment interruptions (STIs). The frequency of HLA-A*2402-restricted CTLs… CONTINUE READING