HLA-A*0206 with TLR3 Polymorphisms Exerts More than Additive Effects in Stevens-Johnson Syndrome with Severe Ocular Surface Complications

@inproceedings{Ueta2012HLAA0206WT,
  title={HLA-A*0206 with TLR3 Polymorphisms Exerts More than Additive Effects in Stevens-Johnson Syndrome with Severe Ocular Surface Complications},
  author={M Ueta and Katsushi Tokunaga and Chie Sotozono and Hiromi Sawai and Gen Tamiya and Tsutomu Inatomi and Shigeru Kinoshita},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Stevens-Johnson syndrome (SJS) is an acute inflammatory vesiculobullous reaction of the skin and mucosa, often including the ocular surface, and toxic epidermal necrolysis (TEN) occurs with its progression. Although SJS/TEN is thought to be initiated by certain types of medication coupled with possible infection. In the present study we examined the multiplicative interaction(s) between HLA-A*0206 and 7 Toll-like receptor 3 (TLR3) Single-nucleotide polymorphisms (SNPs) in patients… CONTINUE READING
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