HLA-A*0201 restricted CD8+ T-lymphocyte responses to malaria: identification of new Plasmodium falciparum epitopes by IFN-gamma ELISPOT.

@article{Gonzlez2000HLAA0201RC,
  title={HLA-A*0201 restricted CD8+ T-lymphocyte responses to malaria: identification of new Plasmodium falciparum epitopes by IFN-gamma ELISPOT.},
  author={J M Gonz{\'a}lez and Katrin Peter and F. Esposito and Issa O N{\'e}bi{\'e} and J. M. Tiercy and Anilza Bonelo and Myriam Ar{\'e}valo-Herrera and Danila Valmori and Pedro Romero and S{\'o}crates Herrera and Giampietro Corradin and Jose Alejandro Poveda Lopez},
  journal={Parasite immunology},
  year={2000},
  volume={22 10},
  pages={501-14}
}
The role of antigen specific CD8+ T-lymphocytes in mediating protection against sporozoite-induced malaria has been well established in murine models. In humans, indirect evidence has accumulated suggesting a similar protective role for antigen-specific CD8+ T-lymphocytes. Nevertheless, the low frequency of circulating specific cells together with the lack of sensitive methods to quantify them has hampered the direct assessment of their function. Using a combination of short-term cell culture… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…