HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma.

@article{Niens2007HLAA02IA,
  title={HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma.},
  author={Marijke Niens and Ruth F. Jarrett and Bouke G. Hepkema and Ilja M. Nolte and Arjan Diepstra and Mathieu Platteel and Niels Kouprie and Craig P. Delury and Alice Gallagher and Lydia Visser and Sibrand Poppema and Gerard J. te Meerman and Anke van den Berg},
  journal={Blood},
  year={2007},
  volume={110 9},
  pages={3310-5}
}
Previous studies showed that the HLA class I region is associated with Epstein-Barr virus (EBV)-positive Hodgkin lymphoma (HL) and that HLA-A is the most likely candidate gene in this region. This suggests that antigenic presentation of EBV-derived peptides in the context of HLA-A is involved in the pathogenesis of EBV+ HL by precluding efficient immune responses. We genotyped exons 2 and 3, encoding the peptide-binding groove of HLA-A, for 32 single nucleotide polymorphisms in 70 patients with… CONTINUE READING

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