HLA/KIR restraint of HIV: surviving the fittest.

  title={HLA/KIR restraint of HIV: surviving the fittest.},
  author={Arman A. Bashirova and Rasmi Thomas and Mary N Carrington},
  journal={Annual review of immunology},
Multiple epidemiological studies have demonstrated associations between the human leukocyte antigen (HLA) loci and human immunodeficiency virus (HIV) disease, and more recently the killer cell immunoglobulin-like (KIR) locus has been implicated in differential responses to the virus. Genome-wide association studies have convincingly shown that the HLA class I locus is the most significant host genetic contributor to the variation in HIV control, underscoring a central role for CD8 T cells in… CONTINUE READING
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