HJURP is involved in the expansion of centromeric chromatin

Abstract

The CENP-A-specific chaperone HJURP mediates CENP-A deposition at centromeres. The N-terminal region of HJURP is responsible for binding to soluble CENP-A. However, it is unclear whether other regions of HJURP have additional functions for centromere formation and maintenance. In this study, we generated chicken DT40 knockout cell lines and gene replacement… (More)
DOI: 10.1091/mbc.E15-02-0094

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