HIV vector-mediated targeted suicide gene therapy for adult T-cell leukemia

@article{Miyake2007HIVVT,
  title={HIV vector-mediated targeted suicide gene therapy for adult T-cell leukemia},
  author={Koichi Miyake and Koiti Inokuchi and Naoko Miyake and Kazuo Dan and Takashi L Shimada},
  journal={Gene Therapy},
  year={2007},
  volume={14},
  pages={1662-1667}
}
We investigated the potential efficacy of treating adult T-cell leukemia (ATL) using a gene therapeutic approach involving the use of a herpes simplex virus–thymidine kinase (HSV-TK)-mediated suicide system. Human immunodeficiency virus (HIV)-based vectors containing the HSV-TK gene were constructed to achieve targeted gene transfer into CD4-positive ATL cells, after which the transduced cells were selectively killed by treatment with ganciclovir (GCV). To examine the utility of HIV vectors in… CONTINUE READING
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