HIV type 1 vaccines for worldwide use: predicting in-clade and cross-clade breadth of immune responses.

@article{Finnefrock2007HIVT1,
  title={HIV type 1 vaccines for worldwide use: predicting in-clade and cross-clade breadth of immune responses.},
  author={Adam C. Finnefrock and Xiaomei Liu and David W Opalka and John Shiver and Danilo R. Casimiro and Jon Condra},
  journal={AIDS research and human retroviruses},
  year={2007},
  volume={23 10},
  pages={1283-92}
}
One of the greatest challenges in HIV vaccine development is accommodating the worldwide sequence diversity of the HIV-1 virus. To understand how viral sequence diversity may affect the potential breadth of HIV-1 vaccines designed to elicit antiviral T cell immunity, we have developed novel approaches to assess sequence conservation at the amino acid level, where vaccine effects are exerted. Taking each sequence from the LANL 2004 amino acid alignments as a potential vaccine or as a challenge… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…