HIV-specific cytotoxic T lymphocytes traffic to lymph nodes and localize at sites of HIV replication and cell death

A variety of inferential evidence suggests that cytotoxic T lymphocytes (CTL) can exert substantial anti-HIV activity (1–3), including dramatic reductions in cellfree (4, 5) and cell-associated (6, 7) virus with corresponding increases in CD4+ T cells (5, 8, 9). Still, hostmediated immune responses to HIV generally fail to completely control virus… CONTINUE READING