HIV-specific Cytotoxic T Cells from Long-Term Survivors Select a Unique T Cell Receptor

Abstract

HIV-specific cytotoxic T lymphocytes (CTL) are important in controlling HIV replication, but the magnitude of the CTL response does not predict clinical outcome. In four donors with delayed disease progression we identified Vbeta13.2 T cell receptors (TCRs) with very similar and unusually long beta-chain complementarity determining region 3 (CDR3) regions… (More)

Topics

6 Figures and Tables