HIV-specific CD8⁺ T cells and HIV eradication.

  title={HIV-specific CD8⁺ T cells and HIV eradication.},
  author={Richard B. Jones and Bruce D. Walker},
  journal={The Journal of clinical investigation},
  volume={126 2},
After the success of combination antiretroviral therapy (cART) to treat HIV infection, the next great frontier is to cure infected persons, a formidable challenge. HIV persists in a quiescent state in resting CD4+ T cells, where the replicative enzymes targeted by cART are not active. Although low levels of HIV transcripts are detectable in these resting cells, little to no viral protein is produced, rendering this reservoir difficult to detect by the host CD8+ T cell response. However, recent… CONTINUE READING
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