HIV-specific CD8+ T cells from elite controllers are primed for survival.

  title={HIV-specific CD8+ T cells from elite controllers are primed for survival.},
  author={Jiyu Yan and Steffanie Sabbaj and Anju Bansal and Nilesh Amatya and John Shacka and Paul A Goepfert and Sonya L Heath},
  journal={Journal of virology},
  volume={87 9},
HIV-specific cytotoxic T lymphocytes (CTL) are preferentially primed for apoptosis, and this may represent a viral escape mechanism. We hypothesized that HIV-infected individuals that control virus to undetectable levels without antiretroviral therapy (ART) (elite controllers [EC]) have the capacity to upregulate survival factors that allow them to resist apoptosis. To address this, we performed cross-sectional and longitudinal analysis of proapoptotic (cleaved caspase-3) and antiapoptotic (Bcl… CONTINUE READING
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