HIV secreted protein Tat prevents long-term potentiation in the hippocampal CA1 region

@article{Behnisch2004HIVSP,
  title={HIV secreted protein Tat prevents long-term potentiation in the hippocampal CA1 region},
  author={Thomas Behnisch and Walter Francesconi and Pietro Paolo Sanna},
  journal={Brain Research},
  year={2004},
  volume={1012},
  pages={187-189}
}
  • Thomas Behnisch, Walter Francesconi, Pietro Paolo Sanna
  • Published in Brain Research 2004
  • Medicine, Biology
  • HIV-associated dementia (HAD) is a complication of advanced HIV disease. Both viral products and host cytokines are believed to be involved in the pathogenesis of HIV-associated neurological manifestations. Among the viral products released by HIV-infected cells is the soluble protein Tat. We investigated the effect of exposure of organotypic hippocampal slices to 100 nM recombinant Tat 1-86 on long-term potentiation (LTP) of field excitatory postsynaptic potential (fEPSP) at Schaffer… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 20 CITATIONS

    Conditional Tat protein expression in the GT-tg bigenic mouse brain induces gray matter density reductions

    VIEW 7 EXCERPTS
    CITES BACKGROUND & RESULTS
    HIGHLY INFLUENCED