HIV reverse transcriptase structure-function relationships.

  title={HIV reverse transcriptase structure-function relationships.},
  author={Alfredo Jacobo-Molina and Eddy Arnold},
  volume={30 26},
HIV reverse transcriptase (RT) is the target of the most widely used treatments for AIDS. Biochemical and mutagenesis studies performed on HIV-1 RT are reviewed in light of the enzyme's structure and functions. Features described include domain arrangement, dimerization, proteolytic processing, and specific recognition of the priming tRNA. Possible regions of functional importance as determined by comparative amino acid sequence analysis and by site-directed mutagenesis are identified. Among… CONTINUE READING


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