HIV reservoirs: what, where and how to target them

  title={HIV reservoirs: what, where and how to target them},
  author={Melissa J. Churchill and Steven G. Deeks and David M Margolis and Robert F. Siliciano and R. Swanstrom},
  journal={Nature Reviews Microbiology},
One of the main challenges in the fight against HIV infection is to develop strategies that are able to eliminate the persistent viral reservoir that harbours integrated, replication-competent provirus within host cellular DNA. This reservoir is resistant to antiretroviral therapy (ART) and to clearance by the immune system of the host; viruses originating from this reservoir lead to rebound viraemia once treatment is stopped, giving rise to new rounds of infection. Several studies have focused… CONTINUE READING

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