HIV rebounds from latently infected cells, rather than from continuing low-level replication.

@article{Joos2008HIVRF,
  title={HIV rebounds from latently infected cells, rather than from continuing low-level replication.},
  author={Beda Joos and Marek Fischer and Herbert Kuster and Satish Pillai and Joseph K Wong and J{\"u}rg B{\"o}ni and Bernard Hirschel and Rainer K. Weber and Alexandra Trkola and Huldrych F. G{\"u}nthard},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 43},
  pages={16725-30}
}
Rapid rebound of plasma viremia in patients after interruption of long-term combination antiretroviral therapy (cART) suggests persistence of low-level replicating cells or rapid reactivation of latently infected cells. To further characterize rebounding virus, we performed extensive longitudinal clonal evolutionary studies of HIV env C2-V3-C3 regions and exploited the temporal relationships of rebounding plasma viruses with regard to pretreatment sequences in 20 chronically HIV-1-infected… CONTINUE READING

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