HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms.

@article{Hartkoorn2010HIVPI,
  title={HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms.},
  author={Ruben C. Hartkoorn and Wai San Kwan and Victoria Shallcross and Ammara Chaikan and Neill James Liptrott and Deirdre Egan and Enrique Salcedo Sora and Chlo{\"e} E. James and Sara Gibbons and Pat G Bray and David J. Back and Saye Khoo and Andrew Owen},
  journal={Pharmacogenetics and genomics},
  year={2010},
  volume={20 2},
  pages={
          112-20
        }
}
OBJECTIVE OATP1B1 and OATP1B3 are major hepatic drug transporters whilst OATP1A2 is mainly located in the brain but is also located in liver and several other organs. These transporters affect the distribution and clearance of many endobiotics and xenobiotics and have been reported to have functional single nucleotide polymorphisms (SNPs). We have assessed the substrate specificities of these transporters for a panel of antiretrovirals and investigated the effects of SNPs within these… CONTINUE READING
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