HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma

@article{Sgadari2002HIVPI,
  title={HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma},
  author={Cecilia Sgadari and Giovanni Barillari and Elena Toschi and Davide Carlei and Ilaria Bacigalupo and Sara Baccarini and Clelia Palladino and Patrizia Leone and Roberto Bugarini and Laura Malavasi and Aurelio Cafaro and Mario Falchi and Donatella Valdembri and Giovanni Rezza and Federico Bussolino and Paolo Monini and Barbara Ensoli},
  journal={Nature Medicine},
  year={2002},
  volume={8},
  pages={225-232}
}
Treatment with HIV-1 protease inhibitors (PI) is associated with a reduced incidence or regression of Kaposi sarcoma (KS). Here we show that systemic administration of the PIs indinavir or saquinavir to nude mice blocks the development and induces regression of angioproliferative KS-like lesions promoted by primary human KS cells, basic fibroblast growth factor (bFGF), or bFGF and vascular endothelial growth factor (VEGF) combined. These PIs also block bFGF or VEGF-induced angiogenesis in the… CONTINUE READING

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