HIV protease inhibitor ritonavir increases endothelial monolayer permeability.

@article{Chen2005HIVPI,
  title={HIV protease inhibitor ritonavir increases endothelial monolayer permeability.},
  author={Changyi Johnny Chen and Xiang-huai Lu and Shaoyu Yan and Hong Chai and Q. -S. Yao},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={335 3},
  pages={874-82}
}
HIV protease inhibitors (PIs) are often associated with metabolic and cardiovascular complications although they are effective anti-HIV drugs. In this study, we determined whether HIV PI ritonavir could increase endothelial permeability, one of the important mechanisms of vascular lesion formation. Human dermal microvascular endothelial cells (HMECs) treated with ritonavir showed a significant increase of endothelial permeability in a dose- and time-dependent manner assayed with a transwell… CONTINUE READING