HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833.

@article{Drewe1999HIVPI,
  title={HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833.},
  author={Juergen Drewe and H. Cem Gutmann and Gert Fricker and Michael T{\"o}r{\"o}k and Christoph Beglinger and Joerg Huwyler},
  journal={Biochemical pharmacology},
  year={1999},
  volume={57 10},
  pages={1147-52}
}
The effect of P-glycoprotein inhibition on the uptake of the HIV type 1 protease inhibitor saquinavir into brain capillary endothelial cells was studied using porcine primary brain capillary endothelial cell monolayers as an in vitro test system. As confirmed by polymerase chain reaction and Western blot analysis, this system functionally expressed class I P-glycoprotein (pgp1A). P-Glycoprotein isoforms pgp1B or pgp1D could not be detected. The uptake of saquinavir into endothelial cells could… CONTINUE READING
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