HIV pathogenesis: dynamics and genetics of viral populations and infected cells.

Abstract

In the absence of treatment, HIV-1 infection, usually starting with a single virion, leads inexorably to a catastrophic decline in the numbers of CD4(+) T cells and to AIDS, characterized by numerous opportunistic infections as well as other symptoms, including dementia and wasting. In the 30 years since the AIDS pandemic came to our attention, we have… (More)
DOI: 10.1101/cshperspect.a012526

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@article{Coffin2013HIVPD, title={HIV pathogenesis: dynamics and genetics of viral populations and infected cells.}, author={John M Coffin and Ronald I. Swanstrom}, journal={Cold Spring Harbor perspectives in medicine}, year={2013}, volume={3 1}, pages={a012526} }