HIV neuropathy

@article{Kaku2014HIVN,
  title={HIV neuropathy},
  author={Michelle C Kaku and David M. Simpson},
  journal={Current Opinion in HIV and AIDS},
  year={2014},
  volume={9},
  pages={521–526}
}
Purpose of reviewTo present an overview of HIV-associated distal symmetric polyneuropathy (HIV-DSP) and other HIV-related peripheral neuropathies in the post-highly active retroviral therapy era. Recent findingsHIV-DSP has become the most common neurologic complication of HIV largely due to the prolonged survival of HIV-positive patients with the advent of highly active retroviral therapy. HIV-DSP can be attributed to the disease itself or to secondary effects of certain HAART agents, and often… 
Peripheral Neuropathy in HIV: An Analysis of Evidence‐based Approaches
Comorbid Pain Syndromes in HIV-Associated Peripheral Neuropathy
TLDR
Clinicians managing HIV-PN should seek a broad understanding of patients' pain experience as this may alter management strategies and how the presence of other pain disorders might affect outcomes.
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TLDR
Further neurological research in low-income and middle-income countries (LMICs) is needed to address the burden of neurological complications in HIV-positive patients, particularly regarding CNS viral reservoirs and their effects on eradication.
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TLDR
In HIV patients, objective signs of neuropathy correlated with smaller cerebellar vermis volumes whereas subjective symptoms of Neuropathy were associated with smaller precuneus volumes, consistent with the recent contention that ART-treated HIV-related neuropathy has a CNS component.
Autoimmune and Infectious Neuropathies
  • A. Abuzinadah, C. Gibbons
  • Medicine, Biology
    Small Fiber Neuropathy and Related Syndromes: Pain and Neurodegeneration
  • 2019
TLDR
Therapeutic interventions will focus on treatment of the underlying disease with symptomatic management of the pain and autonomic symptoms, and the presence of non-length-dependent pattern of sensory loss suggests an immune-mediated disorder, while patchy nerve fiber involvement suggests a vasculitic etiology.
Predictive variables for peripheral neuropathy in treated HIV-1 infection revealed by machine learning.
TLDR
Machine learning models uncovered variables related to PNP that were undetected by conventional analyses, emphasizing the importance of statistical algorithmic approaches to understanding complex neurological syndromes.
Mononeuritis multiplex: an uncommon neurological manifestation of cytomegalovirus reactivation in an HIV-infected patient
TLDR
Combination therapy with ganciclovir and foscarnet should be considered for all forms of neurological involvement, although available data are scarce and since there is significant overlap between CMV encephalitis and HIV encephalopathy, ART drugs with higher CSF penetration may have to be considered.
Over-reported peripheral neuropathy symptoms in a cohort of HIV infected and uninfected Rwandan women: the need for validated locally appropriate questionnaires.
TLDR
The rate of peripheral neuropathy symptoms reported in this cohort of HIV-infected African women seems implausible, and rather suggests that the screening tool for peripheral Neuropathy in culturally diverse African settings be locally validated.
Persistent Peripheral Nervous System Damage in Simian Immunodeficiency Virus–Infected Macaques Receiving Antiretroviral Therapy
TLDR
Findings illustrate that significant PNS damage persists in SIV-infected macaques on suppressive cART, and indicates that antiretroviral toxic neuropathy in some patients is clinically indistinguishable from the sensory neuropathy induced by HIV.
A Comparison of Neuropathic Pain in HIV Disease and Diabetes Mellitus
TLDR
Both groups had paralinguistic and nonverbal elements discovered in the recordings demonstrating the need for future research to explore these components, and one contrasting theme, privacy, was detected in the HIV-PN group, correlating statistically with the Beck Depression Inventory findings of guilt feelings.
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