HIV infection reveals widespread expansion of novel centromeric human endogenous retroviruses.

@article{ContrerasGalindo2013HIVIR,
  title={HIV infection reveals widespread expansion of novel centromeric human endogenous retroviruses.},
  author={Rafael Contreras-Galindo and Mark H Kaplan and Shengshuang. He and Angie C Contreras-Galindo and Marta Jeannette Gonzalez-Hernandez and Ferdinand Kappes and Derek Dube and Susana M. Chan and David B. Robinson and Fan Meng and Manhong Dai and Scott D. Gitlin and Arul M. Chinnaiyan and Gilbert S. Omenn and David M Markovitz},
  journal={Genome research},
  year={2013},
  volume={23 9},
  pages={
          1505-13
        }
}
Human endogenous retroviruses (HERVs) make up 8% of the human genome. The HERV-K (HML-2) family is the most recent group of these viruses to have inserted into the genome, and we have detected the activation of HERV-K (HML-2) proviruses in the blood of patients with HIV-1 infection. We report that HIV-1 infection activates expression of a novel HERV-K (HML-2) provirus, termed K111, present in multiple copies in the centromeres of chromosomes throughout the human genome yet not annotated in the… CONTINUE READING
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