HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation.

@article{Dion2004HIVIR,
  title={HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation.},
  author={Marie-Lise Dion and Jean-François Poulin and Rebeka Bordi and Myriam Sylvestre and Rachel Corsini and Nadia Kettaf and Ali H. Dalloul and M. -R. Boulassel and Patrice Debr{\'e} and Jean-pierre Routy and Zvi Grossman and Rafick Pierre S{\'e}kaly and R{\'e}mi Cheynier},
  journal={Immunity},
  year={2004},
  volume={21 6},
  pages={757-68}
}
The supply of naive T cells by the thymus normally requires precursor T cell proliferation within the thymus and would be particularly important in the setting of HIV infection when both naive and memory T cells are progressively depleted. As a robust, quantitative index of intrathymic proliferation, the ratio of different T cell receptor excision circles (TRECs), molecular markers of distinct T cell receptor rearrangements occurring at different stages of thymocyte development, was measured in… CONTINUE READING