HIV infection of the BS-1 human stroma cell line: effect on murine hematopoiesis.

@article{Steinberg1993HIVIO,
  title={HIV infection of the BS-1 human stroma cell line: effect on murine hematopoiesis.},
  author={Harry N. Steinberg and Jenny Anderson and Clyde S. Crumpacker and Pamela A Chatis},
  journal={Virology},
  year={1993},
  volume={193 1},
  pages={524-7}
}
BS-1, a stroma cell line derived from normal human bone marrow, can support the growth of murine erythroid (BFU-E), granulocyte-macrophage (CFU-GM), and megakaryocyte (CFU-Meg) progenitor cells in a short-term in vitro coculture system. Exposure of BS-1 cell to the human immunodeficiency virus (HIV) prior to coculture results in a marked reduction in the stroma cell's ability to support murine BFU-E and CFU-GM. The effect of HIV on the BS-1 cell's hematopoietic support function (HSF) is… CONTINUE READING