HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production.

@article{Harman2011HIVIO,
  title={HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production.},
  author={Andrew N Harman and Joey Lai and Stuart G. Turville and Shamith A. Samarajiwa and Lachlan Gray and Valerie Marsden and Sarah K. Mercier and Kate Jones and Najla Nasr and Arjun Rustagi and Helen Cumming and Heather Donaghy and Johnson Mak and Michael Gale and Melissa Churchill and Paul J. Hertzog and Anthony L Cunningham},
  journal={Blood},
  year={2011},
  volume={118 2},
  pages={298-308}
}
Many viruses have developed mechanisms to evade the IFN response. Here, HIV-1 was shown to induce a distinct subset of IFN-stimulated genes (ISGs) in monocyte-derived dendritic cells (DCs), without detectable type I or II IFN. These ISGs all contained an IFN regulatory factor 1 (IRF-1) binding site in their promoters, and their expression was shown to be driven by IRF-1, indicating this subset was induced directly by viral infection by IRF-1. IRF-1 and -7 protein expression was enriched in HIV… CONTINUE READING