HIV-infected humans, but not chimpanzees, have circulating cytotoxic T lymphocytes that lyse uninfected CD4+ cells.

@article{Zarling1990HIVinfectedHB,
  title={HIV-infected humans, but not chimpanzees, have circulating cytotoxic T lymphocytes that lyse uninfected CD4+ cells.},
  author={Joyce M. Zarling and Jeffrey A. Ledbetter and Joan Sias and P. Fultz and Jorg W. Eichberg and George F. Gjerset and Patricia A. Moran},
  journal={Journal of immunology},
  year={1990},
  volume={144 8},
  pages={2992-8}
}
It has been suggested that autoimmune phenomena contribute to the depletion of CD4+ T cells and the development of AIDS in HIV-1 infected humans based, in part, on observations that some HIV-1-infected humans have autoantibodies reactive with Ag expressed on uninfected CD4+ cells. In this study, 11 of 14 asymptomatic HIV-1-infected homosexuals and hemophiliacs, but none of 17 uninfected homosexuals or heterosexuals, were found to have cytotoxic lymphocytes in blood that can lyse uninfected CD4… CONTINUE READING

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