HIV immune evasion disruption of antigen presentation by the HIV Nef protein.


The Human Immunodeficiency Virus (HIV) Nef protein is necessary for high viral loads and for timely progression to AIDS. Nef plays a number of roles, but its effect on antigen presentation and immune evasion are among the best characterized. Cytotoxic T lymphocytes (CTLs) recognize and lyse virally infected cells by detecting viral antigens in complex with… (More)
DOI: 10.1016/B978-0-12-385987-7.00005-1

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