HIV gp41 fusion peptide increases membrane ordering in a cholesterol-dependent fashion.

@article{Lai2014HIVGF,
  title={HIV gp41 fusion peptide increases membrane ordering in a cholesterol-dependent fashion.},
  author={Alex L. Lai and Jack H. Freed},
  journal={Biophysical journal},
  year={2014},
  volume={106 1},
  pages={172-81}
}
Fusion between viral envelopes and host cell membranes, which is mediated by special glycoproteins anchored on the viral membrane, is required for HIV viral entry and infection. The HIV gp41 fusion peptide (FP), which initiates membrane fusion, adopts either an α-helical or β-sheeted structure depending on the cholesterol concentration. We used phosphocholine spin labels on the lipid headgroup and different positions on the acyl chain to detect its perturbation on lipid bilayers containing… CONTINUE READING

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