HIV gp41 C-terminal heptad repeat contains multifunctional domains. Relation to mechanisms of action of anti-HIV peptides.

@article{Liu2007HIVGC,
  title={HIV gp41 C-terminal heptad repeat contains multifunctional domains. Relation to mechanisms of action of anti-HIV peptides.},
  author={Shuwen Liu and Weiguo Jing and Byron Cheung and Hong Li Lu and Jane S. Sun and Xuxia Yan and Jinkui Niu and James G Farmar and Shuguang Wu and Shibo Jiang},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 13},
  pages={9612-20}
}
T20 (Fuzeon), a novel anti-human immunodeficiency virus (HIV) drug, is a peptide derived from HIV-1 gp41 C-terminal heptad repeat (CHR). Its mechanism of action has not yet been defined. We applied Pepscan strategy to determine the relationship between functional domains and mechanisms of action of five 36-mer overlapping peptides with a shift of five amino acids (aa): CHR-1 (aa 623-658), C36 (aa 628-663), CHR-3 (aa 633-668), T20 (aa 638-673), and CHR-5 (aa 643-678). C36 is a peptide with… CONTINUE READING
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