HIV evolution: CTL escape mutation and reversion after transmission

  title={HIV evolution: CTL escape mutation and reversion after transmission},
  author={Alasdair J. Leslie and Katja J. Pfafferott and Polan Chetty and Rika Draenert and Marylyn Martina Addo and Morgan Anne Feeney and Yanhua Tang and Edward C. Holmes and Todd M. Allen and Julia G. Prado and Marcus Altfeld and Christian Brander and Catherine Dixon and Danni Ramduth and Prakash Mohan Jeena and Sarah Ann Thomas and Andrew St John and Timothy A Roach and Bernd Kupfer and G. A. Luzzi and Anne Edwards and Geoffery Taylor and Hermione Lyall and Gareth Tudor-Williams and Vas Novelli and Javier Martinez-Picado and Photini Kiepiela and Bruce D. Walker and Philip J. R. Goulder},
  journal={Nature Medicine},
Within-patient HIV evolution reflects the strong selection pressure driving viral escape from cytotoxic T-lymphocyte (CTL) recognition. Whether this intrapatient accumulation of escape mutations translates into HIV evolution at the population level has not been evaluated. We studied over 300 patients drawn from the B- and C-clade epidemics, focusing on human leukocyte antigen (HLA) alleles HLA-B57 and HLA-B5801, which are associated with long-term HIV control and are therefore likely to exert… CONTINUE READING
Highly Influential
This paper has highly influenced 42 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS