HIV evades RNA interference directed at TAR by an indirect compensatory mechanism.

@article{Leonard2008HIVER,
  title={HIV evades RNA interference directed at TAR by an indirect compensatory mechanism.},
  author={Joshua N. Leonard and Priya S. Shah and John C. Burnett and David V. Schaffer},
  journal={Cell host & microbe},
  year={2008},
  volume={4 5},
  pages={
          484-94
        }
}
HIV can rapidly evolve when placed under selective pressure, including immune surveillance or the administration of antiretroviral drugs. Typically, a variant protein allows HIV to directly evade the selective pressure. Similarly, HIV has escaped suppression by RNA interference (RNAi) directed against viral RNAs by acquiring mutations at the target region that circumvent RNAi-mediated inhibition while conserving necessary viral functions. However, when we directed RNAi against the viral TAR… CONTINUE READING
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