HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cells

@inproceedings{Cicala2006HIVEI,
  title={HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cells},
  author={Claudia Cicala and James Arthos and Elena Martinelli and Nina M. Censoplano and Catherine C. Cruz and Eva A Chung and Sara M. Selig and Donald Van Ryk and Jun Yang and Shyla Jagannatha and Tae Wook Chun and Ping Ren and Richard A. Lempicki and Anthony S. Fauci},
  year={2006}
}
HIV envelope binds to and signals through its primary cellular receptor, CD4, and through a coreceptor, either CC chemokine receptor 5 (CCR5) or CXC chemokine receptor 4 (CXCR4). Here, we evaluate the response of peripheral blood mononuclear cells to a panel of genetically diverse R5 and X4 envelope proteins. Modulation of gene expression was evaluated by using oligonucleotide microarrays. Activation of transcription factors was evaluated by using an array of oligonucleotides encoding… CONTINUE READING