HIV endocytosis after dendritic cell to T cell viral transfer leads to productive virus infection.

  title={HIV endocytosis after dendritic cell to T cell viral transfer leads to productive virus infection.},
  author={Imma Clotet-Codina and B. I. M. ten Bosch and Jordi Senserrich and Maria Teresa Fernandez-Figueras and R Deogracias Pena and Ester Ballana and Margarita Bofill and Bonaventura Clotet and Jos{\'e} A. Est{\'e}},
  journal={Antiviral research},
  volume={83 1},
Contacts between HIV-producing T cells and primary CD4+ T cells may induce the uptake of HIV by target cells that are endocytosed into trypsin-resistant compartments. We have now compared the mechanism of virus transmission from T cell-to-T cell versus infected dendritic cells (DCs)-to-T cell. In cocultures of HIV-1-infected DCs with primary CD4+ T cells, virus transmission to the target cells was resistant to trypsin treatment and could only be prevented by the anti-SUgp120 antibody IgGb12 but… CONTINUE READING
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