HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations

@article{Pocernich2005HIVdementiaTO,
  title={HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations},
  author={Chava B. Pocernich and Rukhsana Sultana and Hafiz Mohmmad-Abdul and Avindra Nath and D Allan Butterfield},
  journal={Brain Research Reviews},
  year={2005},
  volume={50},
  pages={14-26}
}
Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly and indirectly. The role of Tat in HIV-dementia and possible therapeutic strategies involving… CONTINUE READING

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Functions of Tat: the versatile protein of human immunodeficiency virus type 1.

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