HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

@article{Heaton2010HIVassociatedND,
  title={HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors},
  author={Robert K Heaton and Donald R. Franklin and Ronald J. Ellis and John Allen McCutchan and Scott L. Letendre and Shannon LeBlanc and Stephanie Corkran and Nichole A. Duarte and David B. Clifford and Steven Paul Woods and Ann C Collier and Christina M. Marra and Susan Morgello and Monica Rivera Mindt and Michael J. Taylor and Thomas D Marcotte and Joseph Hampton Atkinson and Tanya J Wolfson and Benjamin B. Gelman and Justin C McArthur and David M. Simpson and Ian Abramson and Anthony Collins Gamst and Christine Fennema-Notestine and Terry L. Jernigan and Joseph K. Wong and Igor Grant},
  journal={Journal of Neurovirology},
  year={2010},
  volume={17},
  pages={3 - 16}
}
Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders (HAND) continue to be reported. Because large HIV-infected (HIV+) and uninfected (HIV−) groups have not been studied with similar methods in the pre-CART and CART eras, it is unclear whether CART has changed the prevalence, nature, and clinical correlates of HAND. We used comparable methods of subject screening and… 
Changing clinical phenotypes of HIV-associated neurocognitive disorders
  • N. Sacktor
  • Medicine, Psychology
    Journal of NeuroVirology
  • 2017
TLDR
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TLDR
A moderate rate of mild neurocognitive impairment is still present in young adults with chronic HIV infection acquired in early childhood despite successful cART, without any association with classic markers of HIV infection.
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TLDR
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TLDR
HAND continues to be an important neurological manifestation in both HIV+ individuals naïve to cART and on cART, and ANI has recently been shown to lead to a two-fold to five-fold increased progression to symptomatic HAND.
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TLDR
How cART interacts with HAND in terms of clinical characteristics and biomarkers is discussed and the outcomes of recent clinical studies focused on the CNS penetrating antiretroviral regimens and some novel therapeutic approaches are reviewed.
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TLDR
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Neurocognitive Impairment in Well-Controlled HIV-Infected Patients: A Cross-Sectional Study.
TLDR
Prevalence of NCI is high in otherwise healthy adults with HIV-infection and high IL-6 levels are associated with NCI, and delayed recall ND is worse in patients with subclinical atherosclerosis.
Neurocognitive profile of HIV-positive adults on combined antiretroviral therapy: A single-centre study in Serbia
TLDR
The findings suggest that even with the absence of a subjective experience of cognitive deficits and with a good basic control of the illness, a certain degree of cognitive deficit can be observed in the tested group.
An initial screening for HIV-associated neurocognitive disorders of HIV-1 infected patients in China
TLDR
The present data suggest that CD4 count and viral load cannot predict the severity of HAND, although the prevalence of Handed is similar to previous report in these patients.
Risk Factors Leading to Most Severe Forms of HAND in Adults on cART who Present Suppressed Plasma HIV-1 viral load
TLDR
It is concluded that these individuals present cognitive disorders (eg, memory deficits and/or depression on cART, thereby impairing the activities of daily life, due in part to risk factors emphasized in this study.
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