HIV-associated brain pathology in the United Kingdom: an epidemiological study.


OBJECTIVES To examine the epidemiology of HIV-associated neuropathology in the United Kingdom and to investigate whether the prevalence of different forms of HIV-associated brain pathology varies with exposure category. DESIGN The study was a cross-sectional survey; data was analysed from the Medical Research Council National AIDS Neuropathology database. SETTING Information was gathered from throughout England, Scotland and Wales. SUBJECTS Individuals who died from AIDS in the United Kingdom and had a postmortem examination. The database comprised 7% of all AIDS deaths in the United Kingdom between 1982 and 1993. MAIN OUTCOME Neuropathological diagnoses based on internationally accepted neuropathological terminology of AIDS-related brain lesions. RESULTS HIV encephalitis was the most prevalent pathological diagnosis, occurring in 25.3% [95% confidence interval (CI), 21.0-29.6] of the study sample. Statistically significant independent associations for the occurrence of HIV encephalitis were found for injecting drug use (odds ratio, 6.86; 95% CI, 2.91-16.17), and age less than 30 years at death (odds ratio, 3.58; 95% CI, 1.99-6.44). Vascular lesions were significantly higher among blood product recipients, 95% of whom were haemophiliacs. CONCLUSIONS This was the first epidemiological investigation of HIV-associated brain pathology in the United Kingdom. HIV encephalitis appeared to occur more frequently in injecting drug users and those who died younger. Whereas the findings must be interpreted cautiously, one hypothesis was that differences in the route of transmission may have affected the manifestation of HIV-associated brain damage.

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@article{Davies1997HIVassociatedBP, title={HIV-associated brain pathology in the United Kingdom: an epidemiological study.}, author={Janene Davies and Ian Everall and Scott Weich and Jennifer L. McLaughlin and Francesco Scaravilli and Peter L. Lantos}, journal={AIDS}, year={1997}, volume={11 9}, pages={1145-50} }