HIV antiretroviral treatment alters adipokine expression and insulin sensitivity of adipose tissue in vitro and in vivo.

@article{Lagathu2005HIVAT,
  title={HIV antiretroviral treatment alters adipokine expression and insulin sensitivity of adipose tissue in vitro and in vivo.},
  author={Claire Lagathu and Minji Kim and Mustapha Maachi and Corinne Vigouroux and Pascale Cervera and Jacqueline Capeau and M. Caron and J. P. Bastard},
  journal={Biochimie},
  year={2005},
  volume={87 1},
  pages={65-71}
}
HIV-1-infected patients on antiretroviral therapy frequently develop a lipodystrophy syndrome, characterized by peripheral lipoatrophy and visceral fat redistribution associated with metabolic alterations including dyslipidemia and insulin resistance. Its pathophysiology remains unclear but the antiretroviral treatment, associating protease inhibitors (PIs) and nucleoside analogue inhibitors of the viral reverse transcriptase (NRTIs), plays a major role. Some antiretroviral molecules inhibit… CONTINUE READING
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