HIV Viral Load and Transmissibility of HIV Infection: Undetectable Equals Untransmittable.

  title={HIV Viral Load and Transmissibility of HIV Infection: Undetectable Equals Untransmittable.},
  author={Robert W Eisinger and Carl W Dieffenbach and Anthony S. Fauci},
  volume={321 5},
In 2016, the Prevention Access Campaign, a health equity initiative with the goal of ending the HIV/AIDS pandemic as well as HIV-related stigma, launched the Undetectable = Untransmittable (U = U) initiative.1 U = U signifies that individuals with HIV who receive antiretroviral therapy (ART) and have achieved and maintained an undetectable viral load cannot sexually transmit the virus to others. This concept, based on strong scientific evidence, has broad implications for treatment of HIV… 
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The U = U concept, if expertly packaged by policy-makers, clinicians, health service providers, and HIV control programs, will help to stem the tide of the epidemic in SSA.
HIV-Related Stigma Reduction in the Era of Undetectable Equals Untransmittable: The South Korean Perspective
Key principles for stigma reduction and people-centered approaches in the era of U = U are reviewed and three priorities are identified: 1) immediate intervention in HIV stigma drivers in healthcare settings; 2) social stigma reduction on multiple levels; and 3) collaboration with key populations.
Undisclosed HIV Status to Sex Partners and Its Unintended Consequences in the Era of Undetectable = Untransmittable
Interventions are needed to improve ART adherence and assist men living with HIV in their decisions to disclose HIV status to sex partners and endorsing U=U as a personal HIV prevention strategy predicted undisclosed condomless sex.
Belief, Covariates, and Impact of the "Undetectable = Untransmittable" Message Among People Living with HIV in Australia.
Assessing the perceived personal risk and sexual outcomes in a sample of people living with HIV in Australia found a minority of PLWH with self-reported UDVL thought they could pass on HIV and indicated poor sexual outcomes, including sexual inactivity, reduced frequency of sex, and reduced sexual satisfaction.
Transmission Risk Among Youth Living With HIV in the U.S.
Factors Associated With Virological Suppression of HIV Viral Load in Patients on Antiretroviral Therapy in Conakry, Guinea
The results of this study show viral load suppression greater than 68%.
Association of HIV-syphilis coinfection with optimal antiretroviral adherence: a nation-wide claims study
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Interventions to improve the HIV continuum of care in China
China faces great challenges to reduce HIV sexual transmission, improve the HIV continuum of care, and close the gaps to the UNAIDS Three “90” Targets.
Effects of incentivizing viral suppression in previously incarcerated adults living with HIV
Incentivizing viral suppression can increase viral suppression (undetectable viral load) in people who have been incarcerated.


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The early initiation of antiretroviral therapy reduced rates of sexual transmission of HIV-1 and clinical events, indicating both personal and public health benefits from such therapy.
HIV Transmission Risk Persists During the First 6 Months of Antiretroviral Therapy
Residual HIV transmission risk persists during the first 6 months of ART, with incomplete viral suppression in blood and genital compartments, so other prevention options are needed, such as pre-exposure prophylaxis, until viral suppression is achieved.
Antiretroviral Therapy for the Prevention of HIV-1 Transmission.
The early initiation of ART led to a sustained decrease in genetically linked HIV-1 infections in sexual partners, and was associated with a 93% lower risk of linked partner infection than was delayed ART.
Prevention of HIV-1 infection with early antiretroviral therapy
  • M. Rayment
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  • 2012
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There is a negligible risk of sexual transmission of HIV when an HIV-positive sex partner adheres to antiretroviral therapy and maintains a suppressed viral load of less than 200 copies/mL measured every 4 to 6 months.
Plasma HIV Viral Rebound following Protocol-Indicated Cessation of ART Commenced in Primary and Chronic HIV Infection
Stopping ART initiated in PHI and CHI was associated with viral rebound to levels conferring increased transmission risk, although the level of rebound was significantly lower and sustained in PHI compared to CHI.
PERSONNES SEROPOSITIVES NE SOUFFRANT DAUCUNE AUTRE MST ET SUIVANT UN TRAITEMENT ANTIRETROVIRAL EFFICACE NE TRANSMETTENT PAS LE HIV PAR VOIE SEXUELLE Apres avoir pris connaissance des faits scientifiques, a la demande de la Commission d’experts clinique et therapie VIH et sida (CCT) de l’Office federal de la sante publique
on Antiretroviral Guidelines for Adults and Adolescents
  • Guidelines for the use of antiretroviral agents in adults and adolescents living with HIV. adult-and-adolescent-arv/37/whats-new-in-theguidelines-. October 25, 2018. Accessed January 4,
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Risk of HIV transmission through condomless sex in MSM couples with suppressive ART: the Partners2 Study extended results in gay men
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