HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

  title={HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies},
  author={Jon M. Steichen and Daniel W. Kulp and Talar Tokatlian and Amelia Escolano and Pia Dosenovic and Robyn L Stanfield and Laura E. McCoy and Gabriel Ozorowski and Xiaozhen Hu and Oleksandr Kalyuzhniy and Bryan Briney and Torben Schiffner and Fernando Garces and Natalia Tarnovitski Freund and Alexander D. Gitlin and Sergey Menis and Erik Georgeson and Michael Kubitz and Yumiko Adachi and Meaghan J. Jones and Andrew A. Mutafyan and Dong Soo Yun and Christian T Mayer and Andrew B. Ward and Dennis R. Burton and Ian A. Wilson and Darrell J Irvine and Michel C. Nussenzweig and William R. Schief},
Broadly neutralizing antibodies (bnAbs) against the N332 supersite of the HIV envelope (Env) trimer are the most common bnAbs induced during infection, making them promising leads for vaccine design. Wild-type Env glycoproteins lack detectable affinity for supersite-bnAb germline precursors and are therefore unsuitable immunogens to prime supersite-bnAb responses. We employed mammalian cell surface display to design stabilized Env trimers with affinity for germline-reverted precursors of PGT121… CONTINUE READING
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CryoEM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer

  • D. Lyumkis, J. P. Julien, +7 authors B Carragher
  • Science
  • 2013
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