HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+ T Cells.

@article{Vermere2016HIVTA,
  title={HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+ T Cells.},
  author={Jolien Verme{\'i}re and Ferdinand Roesch and Daniel Sauter and R{\'e}jane Rua and Dominik Hotter and Anouk van Nuffel and Hanne Vanderstraeten and Evelien Naessens and Veronica Iannucci and Alessia Landi and Wojciech Witkowski and Ann Baeyens and Frank Kirchhoff and Bruno Verhasselt},
  journal={Cell reports},
  year={2016},
  volume={17 2},
  pages={413-424}
}
Several pattern-recognition receptors sense HIV-1 replication products and induce type I interferon (IFN-I) production under specific experimental conditions. However, it is thought that viral sensing and IFN induction are virtually absent in the main target cells of HIV-1 in vivo. Here, we show that activated CD4+ T cells sense HIV-1 infection through the cytosolic DNA sensor cGAS and mount a bioactive IFN-I response. Efficient induction of IFN-I by HIV-1 infection requires proviral… CONTINUE READING
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