HIV TAT peptide modifies the distribution of DNA nanolipoparticles following convection-enhanced delivery.

Abstract

We evaluated gene transfer using PEGylated bioresponsive nanolipid particles (NLPs) containing plasmid DNA administered by convection-enhanced delivery (CED) into orthotopically implanted U87-MG tumors in rat brain. We hypothesized that attachment of the human immunodeficiency virus trans-acting transcriptional activator peptide (TATp) to pH-sensitive… (More)
DOI: 10.1038/mt.2008.36

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