HIV Salvage Therapy Does Not Require Nucleoside Reverse Transcriptase Inhibitors

@article{Tashima2015HIVST,
  title={HIV Salvage Therapy Does Not Require Nucleoside Reverse Transcriptase Inhibitors},
  author={Karen T. Tashima and Laura M. Smeaton and Carl J. Fichtenbaum and Adriana Andrade and Joseph J Eron and Rajesh T Gandhi and Victoria Anne Johnson and Karin L. Klingman and Justin Ritz and Sally Hodder and Jorge Luiz Santana and Timothy J. Wilkin and Richard H Haubrich},
  journal={Annals of Internal Medicine},
  year={2015},
  volume={163},
  pages={908-917}
}
  • Karen T. Tashima, Laura M. Smeaton, +10 authors Richard H Haubrich
  • Published in Annals of Internal Medicine 2015
  • Medicine
  • Context Nucleoside reverse transcriptase inhibitors (NRTIs) are often included in antiretroviral regimens for treatment-experienced patients with HIV infection, but no randomized, controlled trials have evaluated this approach. Contribution This large randomized, controlled trial in treatment-experienced patients with HIV infection found no difference in either efficacy or safety when NRTIs were included or excluded in initial optimized antiretroviral regimens. More deaths occurred in the group… CONTINUE READING

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