HIV Salvage Therapy Does Not Require Nucleoside Reverse Transcriptase Inhibitors: A Randomized, Controlled Trial.

@article{Tashima2015HIVST,
  title={HIV Salvage Therapy Does Not Require Nucleoside Reverse Transcriptase Inhibitors: A Randomized, Controlled Trial.},
  author={Karen T. Tashima and Laura M. Smeaton and Carl J. Fichtenbaum and Adriana Lyn Hunter Andrade and Joseph J Eron and Rajesh T Gandhi and Victoria Anne Johnson and Karin L. Klingman and Justin Ritz and Sally Hodder and Jorge L Santana and Timothy J. Wilkin and Richard Haubrich},
  journal={Annals of internal medicine},
  year={2015},
  volume={163 12},
  pages={908-17}
}
Context Nucleoside reverse transcriptase inhibitors (NRTIs) are often included in antiretroviral regimens for treatment-experienced patients with HIV infection, but no randomized, controlled trials have evaluated this approach. Contribution This large randomized, controlled trial in treatment-experienced patients with HIV infection found no difference in either efficacy or safety when NRTIs were included or excluded in initial optimized antiretroviral regimens. More deaths occurred in the group… CONTINUE READING

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