HIV Promotes NLRP3 Inflammasome Complex Activation in Murine HIV-Associated Nephropathy.

@article{Haque2016HIVPN,
  title={HIV Promotes NLRP3 Inflammasome Complex Activation in Murine HIV-Associated Nephropathy.},
  author={Shabirul Haque and Xiqian Lan and Hongxiu Wen and Rivka Lederman and Amrita K Chawla and Mohamed Adel Attia and Ramchandra P Bongu and Mohammad Husain and Joanna Mikulak and Moin Saleem and Waldemar Popik and Ashwani Malhotra and Praveen N. Chander and Pravin C. Singhal},
  journal={The American journal of pathology},
  year={2016},
  volume={186 2},
  pages={347-58}
}
Dysregulated growth and loss of podocytes are important features of HIV-associated nephropathy. Recently, HIV was reported to induce a new type of programed cell death, pyroptosis, in T lymphocytes through induction of Nod-like receptor protein 3 (NLRP3) inflammasome complexes. We evaluated the role of HIV in podocyte NLRP3 inflammasome formation both in… CONTINUE READING