HIV Nef-mediated major histocompatibility complex class I down-modulation is independent of Arf6 activity.

@article{Larsen2004HIVNM,
  title={HIV Nef-mediated major histocompatibility complex class I down-modulation is independent of Arf6 activity.},
  author={Jakob E. Larsen and Ramiro H. Massol and Thomas J. F. Nieland and Tomas Kirchhausen},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 1},
  pages={
          323-31
        }
}
HIV Nef has a number of important biological effects, including the down-modulation of several immunological important molecules (CD4, major histocompatibility complex [MHC] class I). Down-modulation of CD4 seems to be via clathrin-dependent endocytosis, whereas down-modulation of MHC class I remains unexplained. Several mutant proteins, including mutations in the small GTPase Arf6, have been used to probe membrane traffic pathways. One such mutant has recently been used to propose that Nef… CONTINUE READING

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