HIV LTR-dependent expression of Bax selectively induces apoptosis in Tat-positive cells.

@article{McCoubrie2004HIVLE,
  title={HIV LTR-dependent expression of Bax selectively induces apoptosis in Tat-positive cells.},
  author={Joanne E McCoubrie and Tulene S. Kendrick and Rodney F. Minchin},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={325 4},
  pages={1459-64}
}
HIV integrates into the host cell genome where it persists for the life of the cell. One approach to reducing viral burden is to selectively eliminate cells containing integrated provirus early following infection. We have used the HIV LTR promoter to selectively express transgenes in human cells positive for the HIV transactivator protein Tat. Transient transfection of Jurkat cells, or Jurkat cells stably expressing Tat (Jurkat-Tat), with a LTR construct containing luciferase reporter gene… CONTINUE READING

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