HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay.

@article{Sunshine2016HIVIS,
  title={HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay.},
  author={Sara S. Sunshine and Rory Kirchner and Sami S Amr and Leandra Mansur and Rimma Shakhbatyan and Michelle Kim and Alberto Bosque and Robert F. Siliciano and Vicente Planelles and Oliver Hofmann and Shannan J Ho Sui and Jonathan Li},
  journal={Journal of virology},
  year={2016},
  volume={90 9},
  pages={4511-4519}
}
UNLABELLED Antiretroviral therapy (ART) is successful in the suppression of HIV but cannot target and eradicate the latent proviral reservoir. The location of retroviral integration into the human genome is thought to play a role in the clonal expansion of infected cells and HIV persistence. We developed a high-throughput targeted sequence capture assay that uses a pool of HIV-specific probes to enrich Illumina libraries prior to deep sequencing. Using an expanded clonal population of ACH-2… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 7 times over the past 90 days. VIEW TWEETS
8 Citations
42 References
Similar Papers

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Identifying HIV variants that rebound after treatment interruption

  • MF Kearney, W Shao, RT Gandhi, BF Keele, JZ. Li
  • Abstr Conf Retrovir Opportunistic Infect,
  • 2015

Residual viremia caused by clonally expanded tumor-infiltrating CD4 cells

  • FR Simonetti, MD Sobolowski, +7 authors F. Maldarelli
  • Abstr Conf Retrovir Opportunistic Infect,
  • 2015

Similar Papers

Loading similar papers…