HIV Impairs TNF-α Mediated Macrophage Apoptotic Response to Mycobacterium tuberculosis

@inproceedings{Patel2007HIVIT,
  title={HIV Impairs TNF-α Mediated Macrophage Apoptotic Response to Mycobacterium tuberculosis},
  author={Naimish R. Patel and Jinping Zhu and Souvenir D. Tachado and Jianmin Zhang and Zhi Jian Wan and Jussi J Saukkonen and Henry Koziel},
  year={2007}
}
The factors that contribute to the exceptionally high incidence of Mycobacterium tuberculosis (MTb) disease in HIV + persons are poorly understood. Macrophage apoptosis represents a critical innate host cell response to control MTb infection and limit disease. In the current study, virulent live or irradiated MTb (iMTbRv) induced apoptosis of differentiated human U937 macrophages in vitro, in part dependent on TNF-α. In contrast, apoptosis of differentiated HIV + human U1 macrophages (HIV… CONTINUE READING

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